New diagnostic possibilities in systemic neonatal infections: metabolomics

The best diagnostic approach for systemic neonatal infections

Introduction The difficulty to set up a diagnostic model to improve actual medical care results [1], depends on the varieties of clinical presentations for serious infections in the newborn and on his biophysical features. Additionally, many anamnestic risk factors [2] (chorioamnionitis, positive vagino-rectal colture swabs for GBS) or care risk factors (invasive procedures) potentially involve...

Pentacam opens eyes to new diagnostic possibilities

Kindler syndrome: a new mutation and new diagnostic possibilities.

BACKGROUND Kindler syndrome (KS) is a rare genetic disorder that is characterized by blistering in infancy, followed by the onset of poikiloderma and photosensitivity in childhood. The recently elucidated molecular pathogenesis involves mutations in KIND1, a gene encoding the protein kindlin-1, which is involved in the attachment of the actin cytoskeleton to the extracellular matrix in basal ke...

Metabolomics and Exercise: possibilities and perspectives

Aim: This review aimed to provide an overview of the publications using metabolomics in research with physical exercises and to demonstrate how researchers have been applying this approach. Methods: A systematic search in the databases Web of Science, SCOPUS and PubMed was performed, with the key words: “metabolomics” OR “metabonomics” and with “metabolomics” OR “metabonomics” AND “exercise” in...

New diagnostic and therapeutic possibilities for diastolic heart failure.

Despite the fact that up to half of all heart failure occurs in patients without evidence of systolic cardiac dysfunction, there are no universally accepted diagnostic markers and no approved therapies for heart failure with preserved ejection fraction (HFpEF). HFpEF, otherwise known as diastolic heart failure, has nearly the same grim prognosis as systolic heart failure, and diastolic heart fa...